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The Euro Fed Lipid Job Market

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published 20 July 2010
A 1 year post-doctoral position starting before the end of  2010 is open at the INSERM UMR 866, “Lipids, Nutrition, Cancer” 6 Bd Gabriel, 21 000 DIJON, France.  The concerned research team is composed of 7 researchers, 2 engineers and 4 PhD students and focuses his studies on PUFA metabolism related to metabolic syndrome, atherosclerosis and cancer. 
The net salary will be about 2.000 euros/month (2.635 US $).

Project title: The fat-1 transgenic mouse converts Omega-6 fatty acids in Omega-3: does it represent a breast cancer resistant model?

Profile: The candidate must have a solid background in cancer, molecular and cellular biology, cell culture.  Knowledges in polyunsaturated fatty acid biosynthesis, metabolism and analysis (gas liquid chromatography) are appreciated. Experience in the use and care of transgenic animals (breeding, genotyping) is required. The candidate should have passed his/her PhD thesis for less than 2 years except if he/she already got a postdoctoral position. This position is only open to a non-french candidate.

Further information can be asked to:
Dr. Jérôme BELLENGER
E-mail : jerome.bellenger@u-bourgogne.fr

Letters of application, including a CV, the names, postal and e-mail addresses of three academic referees, should be sent to the above address.

Closing date: November 31st, 2010.

Summary of the project :
Nowadays, breast cancer is the most frequent of feminine cancer in the Western Europe, North America and Japan. Contrary to the other breast cancer risk factors (like reproductive factors), food supply can be the object of a primary prevention, by means of an adequate modification of the food customs. However, the role of the diet, in particular that of the lipids and fatty acids, is not yet established with conviction because the data available on the diet remain still very controversial. However, the n-3 polyunsaturated fatty acids (PUFA) are the most promising molecules in the field of the breast cancer prevention.
Rather than the contributions in n-3 and n-6 PUFA taken individually, several experimental studies suggest that the appearance or not of the breast cancer could depend on the balance between these two series of PUFA. Although dietary supplementation with n 3 PUFA is a safe intervention to restore an n-6/n-3 ratio close to 2-5:1, it has a number of limitations. The achievement of a significant in vivo increase of n 3 PUFA tissue concentrations requires a chronic intake of high doses of n 3 PUFA for a period of several months. Moreover, feeding animals with different diets that consist of many components derived from different materials can bring in many variations between the experimental groups. Although the total energy can be balanced, it is difficult to make all the dietary components identical (in both quality and quantity) between two diets. The inevitable differences between diets act as confounding factors in nutritional studies and may contribute to inconsistent or conflicting results. This is the case particularly for studies in the field of lipid (especially n-3 fat) nutrition. Thus the real effects of the dietary n-3 PUFA associated with breast cancer remain ambiguous and need to be clarified.
A gene encoding an n 3 fatty acid desaturase has been cloned from C. elegans. Interestingly, this enzyme catalyzes the conversion of n 6 PUFA to n 3 PUFA by introducing an n 3 double bond into their hydrocarbon chains. The fat-1 gene transferred into murine cells, confers cells the capability of converting n 6 PUFA to corresponding n 3 PUFA, leading to a balanced n 6/n 3 ratio.
Then, the use of fat-1 transgenic mice seems to be such a desirable animal model that can quickly and effectively provide therapeutic and preventive effects of n 3 fatty acids regarding breast cancer, without the need of the ingestion of dietary supplements not easy to control. Compared to  dietary intervention, this approach is more effective in balancing the n 6/n 3 ratio because it not only elevates tissue concentrations of n 3 PUFAs, but it also decreases the levels of excessive endogenous n 6 PUFA.
The objectives of this study are to evidence, using the fat-1 mouse model, the protective effects of n-3 PUFA on the development and progression of mammary breast cancer cells avoiding confounding factors linked to classical nutritional approaches. This model will allow us to better understand the mechanisms of action of the n-3 PUFA involved in breast cancer prevention.

Key words :
breast cancer – n-3 PUFA  –  Fat-1 transgenic mouse model.


Jérôme BELLENGER
UMR INSERM U866
Dislipidemia pathophysiology
Faculté des Sciences Gabriel
6, Bd Gabriel, 21000 DIJON, FRANCE
E-mail : jerome.bellenger@u-bourgogne.fr
Phone : +33 (0) 3 80 39 38 57
Fax : + 33 (0) 3 80 39 63 30


published 27 May 2010
Wiley-VCH seeks applicants for the position of a
co-Editor
for the Lipid Technology monthly magazine

Lipid Technology is a scientific magazine presenting the latest industrial and academic developments in science and technology of lipids, oilseeds, and oils and fats. It covers biotechnology, the oleochemical industry and biodiesel, agriculture, nutrition and the food industry, pharmaceuticals, as well as analytics and commerce.
See www.lipid-technology.com
The focus of the new Editor will mainly be raw materials processing – agronomy, new crops, minor crops, extraction, refining, and oil modification. Initiative in other fields will of course be welcome!
The new Editor should be well connected in the scientific community and have a keen eye for writing and publishing.
Responsibilities of the Editor will cover soliciting, evaluating, and editing short contributions (about 12 per year), and participation in the preparation of monthly Research Highlights – assisted by a Wiley Assistant Editor and an automated online system.
The position is voluntary and an honorarium per published article will be provided. The position is initially for a period of three years, starting as soon as possible.

The future Editor will complete the three-member team of external Editors, currently consisting of Prof.Frank Gunstone, Scottish Crop Research Institute, UK (non-food uses of oils and fats including biodiesel) and Dr. Frédéric Destaillats, Nestlé Research Center, Lausanne, Switzerland (nutrition and food uses).

Contact:
Lipid Technology editorial office:    lipid-technology@wiley.com    T +49 6201 606 231/495
Prof. Frank Gunstone:            fdg1@st-and.ac.uk    T +44 1334 47 99 29



published 14 May 2010
RSSL/Cadbury – Scientist Investigative Analysis (Oils, Fats and Lipids)

Location: Reading, UK
Salary: up to £28k, plus 25 days holiday, pension and bonus scheme

This is an exciting opportunity undertaking analyses for clients both external and internal, in the area of oils and fats, contaminants and other chemical residues. 

You will manage, undertake and perform a range of HPLC and GC investigative and routine analyses, providing support to analytical research projects and key business units.  Driving and supporting method development you will ensure accountabilities and timescales are agreed as well as contribute fully to project planning meetings whilst offering technical support to project managers.

Candidate requirements:

To succeed in this role it’s imperative you have a strong educational history in Biochemistry / Chemistry with a good background knowledge of lipids / oils and fats. A proven track record of relevant laboratory experience, industrial or research is essential.

You must be able to provide evidence of your ability to interpret complex chromatography data (eg. HPLC / GC) and relevant experience of applying that to technical solutions.  Excellent communication skills are essential, including report writing and the presentation of scientific data.

Please note that all candidates must be fully eligible to work in the UK and therefore already hold the relevant right to work documentation (EU passport, VISA etc)

Contact: For further details or to make a formal application please go to:-

www.cadbury.com/careers/currentjobs/Pages/currentjobs
OR
http://www.rssl.com/careers/Pages/careerswithus.aspx

Alternatively please contact our Recruitment hotline: +44 (0) 121 451 0700 or email recruitment@cadbury.com

Reference number: 903

Please quote EuroFed on your application


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