The Euro Fed Lipid
Job
Market
This is the right
place to
post a vacant job within the Fats & Oils area or to post your
resume.
This service is
offered free of charge for members.
Please send the
text you
want to see published here to amoneit@eurofedlipid.org
published
20 July 2010
A 1 year post-doctoral position starting before
the end of 2010 is open at the INSERM UMR 866, “Lipids,
Nutrition, Cancer” 6 Bd Gabriel, 21 000 DIJON, France. The
concerned research team is composed of 7 researchers, 2 engineers and 4
PhD students and focuses his studies on PUFA metabolism related to
metabolic syndrome, atherosclerosis and cancer.
The net
salary will be about 2.000 euros/month (2.635 US $).
Project
title: The fat-1 transgenic mouse converts Omega-6 fatty acids in
Omega-3: does it represent a breast cancer resistant model?
Profile:
The candidate must have a solid background in cancer, molecular and
cellular biology, cell culture. Knowledges in polyunsaturated
fatty acid biosynthesis, metabolism and analysis (gas liquid
chromatography) are appreciated. Experience in the use and care of
transgenic animals (breeding, genotyping) is required. The candidate
should have passed his/her PhD thesis for less than 2 years except if
he/she already got a postdoctoral position. This position is only open
to a non-french candidate.
Further information can be asked to:
Dr.
Jérôme BELLENGER
E-mail : jerome.bellenger@u-bourgogne.fr
Letters
of application, including a CV, the names, postal and e-mail addresses
of three academic referees, should be sent to the above address.
Closing
date: November 31st, 2010.
Summary
of the project :
Nowadays, breast cancer is the most frequent
of feminine cancer in the Western Europe, North America and Japan.
Contrary to the other breast cancer risk factors (like reproductive
factors), food supply can be the object of a primary prevention, by
means of an adequate modification of the food customs. However, the
role of the diet, in particular that of the lipids and fatty acids, is
not yet established with conviction because the data available on the
diet remain still very controversial. However, the n-3 polyunsaturated
fatty acids (PUFA) are the most promising molecules in the field of the
breast cancer prevention.
Rather than the contributions in n-3 and
n-6 PUFA taken individually, several experimental studies suggest that
the appearance or not of the breast cancer could depend on the balance
between these two series of PUFA. Although dietary supplementation with
n 3 PUFA is a safe intervention to restore an n-6/n-3 ratio close to
2-5:1, it has a number of limitations. The achievement of a significant
in vivo increase of n 3 PUFA tissue concentrations requires a chronic
intake of high doses of n 3 PUFA for a period of several months.
Moreover, feeding animals with different diets that consist of many
components derived from different materials can bring in many
variations between the experimental groups. Although the total energy
can be balanced, it is difficult to make all the dietary components
identical (in both quality and quantity) between two diets. The
inevitable differences between diets act as confounding factors in
nutritional studies and may contribute to inconsistent or conflicting
results. This is the case particularly for studies in the field of
lipid (especially n-3 fat) nutrition. Thus the real effects of the
dietary n-3 PUFA associated with breast cancer remain ambiguous and
need to be clarified.
A gene encoding an n 3 fatty acid desaturase
has been cloned from C. elegans. Interestingly, this enzyme catalyzes
the conversion of n 6 PUFA to n 3 PUFA by introducing an n 3 double
bond into their hydrocarbon chains. The fat-1 gene transferred into
murine cells, confers cells the capability of converting n 6 PUFA to
corresponding n 3 PUFA, leading to a balanced n 6/n 3 ratio.
Then,
the use of fat-1 transgenic mice seems to be such a desirable animal
model that can quickly and effectively provide therapeutic and
preventive effects of n 3 fatty acids regarding breast cancer, without
the need of the ingestion of dietary supplements not easy to control.
Compared to dietary intervention, this approach is more effective
in balancing the n 6/n 3 ratio because it not only elevates tissue
concentrations of n 3 PUFAs, but it also decreases the levels of
excessive endogenous n 6 PUFA.
The objectives of this study are to
evidence, using the fat-1 mouse model, the protective effects of n-3
PUFA on the development and progression of mammary breast cancer cells
avoiding confounding factors linked to classical nutritional
approaches. This model will allow us to better understand the
mechanisms of action of the n-3 PUFA involved in breast cancer
prevention.
Key words :
breast cancer – n-3 PUFA
– Fat-1 transgenic mouse model.
Jérôme BELLENGER
UMR
INSERM U866
Dislipidemia pathophysiology
Faculté des Sciences
Gabriel
6, Bd Gabriel, 21000 DIJON, FRANCE
E-mail :
jerome.bellenger@u-bourgogne.fr
Phone : +33 (0) 3 80 39 38 57
Fax
: + 33 (0) 3 80 39 63 30
published
27 May 2010
Wiley-VCH seeks applicants for the position
of a
co-Editor
for the
Lipid Technology monthly magazine
Lipid Technology is a
scientific magazine presenting the latest industrial and academic
developments in science and technology of lipids, oilseeds, and oils
and fats. It covers biotechnology, the oleochemical industry and
biodiesel, agriculture, nutrition and the food industry,
pharmaceuticals, as well as analytics and commerce.
See www.lipid-technology.com
The
focus of the new Editor will mainly be raw materials processing –
agronomy, new crops, minor crops, extraction, refining, and oil
modification. Initiative in other fields will of course be welcome!
The
new Editor should be well connected in the scientific community and
have a keen eye for writing and publishing.
Responsibilities of the
Editor will cover soliciting, evaluating, and editing short
contributions (about 12 per year), and participation in the preparation
of monthly Research Highlights – assisted by a Wiley Assistant Editor
and an automated online system.
The position is voluntary and an
honorarium per published article will be provided. The position is
initially for a period of three years, starting as soon as possible.
The
future Editor will complete the three-member team of external Editors,
currently consisting of Prof.Frank Gunstone, Scottish Crop Research
Institute, UK (non-food uses of oils and fats including biodiesel) and
Dr. Frédéric Destaillats, Nestlé Research Center, Lausanne, Switzerland
(nutrition and food uses).
Contact:
Lipid Technology
editorial office: lipid-technology@wiley.com
T +49 6201 606 231/495
Prof. Frank Gunstone:
fdg1@st-and.ac.uk
T +44 1334 47 99 29
published
14 May 2010
RSSL/Cadbury – Scientist Investigative Analysis (Oils,
Fats and Lipids)
Location: Reading, UK
Salary: up to £28k,
plus 25 days holiday, pension and bonus scheme
This is an
exciting opportunity undertaking analyses for clients both external and
internal, in the area of oils and fats, contaminants and other chemical
residues.
You will manage, undertake and perform a range
of HPLC and GC investigative and routine analyses, providing support to
analytical research projects and key business units. Driving and
supporting method development you will ensure accountabilities and
timescales are agreed as well as contribute fully to project planning
meetings whilst offering technical support to project managers.
Candidate
requirements:
To succeed in this role it’s imperative you have a
strong educational history in Biochemistry / Chemistry with a good
background knowledge of lipids / oils and fats. A proven track record
of relevant laboratory experience, industrial or research is essential.
You
must be able to provide evidence of your ability to interpret complex
chromatography data (eg. HPLC / GC) and relevant experience of applying
that to technical solutions. Excellent communication skills are
essential, including report writing and the presentation of scientific
data.
Please note that all candidates must be fully eligible to
work in the UK and therefore already hold the relevant right to work
documentation (EU passport, VISA etc)
Contact: For further
details or to make a formal application please go to:-
www.cadbury.com/careers/currentjobs/Pages/currentjobs
OR
http://www.rssl.com/careers/Pages/careerswithus.aspx
Alternatively
please contact our Recruitment hotline: +44 (0) 121 451 0700 or email recruitment@cadbury.com
Reference
number: 903
Please quote EuroFed on your application
Back
Home